Opportunity Information: Apply for RFA NS 23 024
The BRAIN Initiative: Targeted BRAIN Circuits Projects (TargetedBCP) funding opportunity (RFA-NS-23-024) is an NIH discretionary grant program using the R01 mechanism, with clinical trials not allowed. It is a reissue of earlier announcements (including RFA-NS-22-026 and originally RFA-NS-18-030) and was updated to comply with NIH data management and sharing policy requirements, with no new submission dates added beyond what was already established. The central purpose of the program is to fund ambitious but tractable neuroscience projects that can deliver a meaningful, clearly defined outcome within a 5-year project period.
At the scientific level, the opportunity is focused on understanding how activity in neural circuits produces mental experience and behavior. NIH is specifically looking for projects that go beyond single-method studies and instead use innovative, methodologically integrated approaches. In practice, that means applicants are expected to combine elements like experimental design, theory, and rigorous data analysis in a way that each component informs the others. A key expectation is that projects will generate predictive models as explicit deliverables, not just descriptive findings. The emphasis is on circuit function within well-defined neural systems tied to core brain operations, including (but not limited to) sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication, and homeostatic regulation.
The research approach NIH is trying to catalyze is one where investigators systematically control stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. In other words, the program favors tightly designed experiments that can establish interpretable links between controlled inputs (stimuli, task demands, behavioral states), circuit-level dynamics (recording), causal perturbations (manipulation), and observed outputs (behavior or measurable mental/physiological states). The goal is to improve understanding of central nervous system circuits in a way that supports generalizable principles and testable predictions, rather than isolated observations.
Species choice is intentionally flexible: projects may use non-human species, human participants, or a combination, as long as the application explains why that species (or set of species) provides especially strong conditions for revealing general principles about the circuit basis of the specific behavior being studied. This places some responsibility on applicants to justify the model system in terms of circuit accessibility, behavioral relevance, available tools for recording/manipulation, and how findings will translate into broader understanding of brain function.
From an administrative standpoint, the opportunity is offered by the National Institutes of Health, with the Funding Opportunity Title listed as "BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)." It is categorized as a grant under a discretionary opportunity category, with activity areas spanning education and health and related social service domains as reflected in the listing. The CFDA numbers associated with the opportunity include 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, and 93.867. The original closing date provided is 2024-05-06, and the posting creation date is 2023-04-26; award ceiling and expected award count are not specified in the provided source details.
Eligibility is broad and includes many common applicant types such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal agencies; faith-based or community-based organizations; regional organizations; U.S. territories or possessions; tribal governments other than federally recognized; and non-domestic (non-U.S.) entities, including foreign organizations. Overall, the program is designed to attract well-justified, integrated circuit neuroscience projects that can produce predictive, model-based outcomes within five years, grounded in carefully controlled experimental logic and strong links between data, theory, and mechanism.Apply for RFA NS 23 024
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2023-04-26.
- Applicants must submit their applications by 2024-05-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional) Apply for RFA MH 23 295 Funding Number: RFA MH 23 295 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 23 290 Funding Number: RFA MH 23 290 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative Partnerships to Advance INterdisciplinary (PAIN) Training in Clinical Pain Research: The HEAL PAIN Cohort Program (T90/R90 Independent Clinical Trial Not Allowed) Apply for RFA NS 24 015 Funding Number: RFA NS 24 015 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed) Apply for PAR 23 199 Funding Number: PAR 23 199 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $220,000 |
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| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 24 280 Funding Number: RFA MH 24 280 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 064 Funding Number: RFA DA 24 064 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 063 Funding Number: RFA DA 24 063 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional) Apply for RFA NS 24 021 Funding Number: RFA NS 24 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 24 012 Funding Number: RFA HD 24 012 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 24 069 Funding Number: RFA DA 24 069 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Methodology and Advanced Analytics Resource Center (UM1 Clinical Trial Not Allowed) Apply for RFA DA 24 068 Funding Number: RFA DA 24 068 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3 - Clinical Trial Optional) Apply for RFA NS 24 023 Funding Number: RFA NS 24 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed) Apply for RFA EY 23 001 Funding Number: RFA EY 23 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| Health and Health Care Disparities Among Persons Living with Disabilities (R01 - Clinical Trials Optional) Apply for PAR 23 309 Funding Number: PAR 23 309 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| Career Enhancement Award to Advance the Study of Intimate Partner Violence (IPV) in the Context of Maternal Morbidity and Mortality Research (K18 Clinical Trial Not Allowed) Apply for RFA OD 24 001 Funding Number: RFA OD 24 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| R25 for Short Courses on Techniques for Measuring Intimate Partner Violence (IPV) in Different Populations (R25 Clinical Trial Not Allowed) Apply for RFA OD 24 002 Funding Number: RFA OD 24 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Understanding the Impact of Healthcare System and Clinician Factors on Disparities in Maternal Morbidity and Mortality (R01 - Clinical Trial Optional) Apply for PAR 24 059 Funding Number: PAR 24 059 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Connectivity across Scales Data Coordinating Center (BRAIN CONNECTS DCC) (U24 Clinical Trial Not Allowed) Apply for RFA NS 24 028 Funding Number: RFA NS 24 028 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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