Opportunity Information: Apply for RFA MD 23 008
The National Institutes of Health (NIH) released this discretionary grant opportunity, RFA-MD-23-008, titled "Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)." It uses the R01 research project grant mechanism and falls under the health funding activity category (CFDA 93.307). The core purpose is to fund research that rigorously tests how well multi-level HIV prevention interventions work for people at the very highest risk of acquiring HIV, especially within health disparity populations or specific subgroups. A key emphasis is on focusing these efforts in one or more geographic areas that are experiencing high rates of new HIV infections, reflecting a place-based approach where local transmission dynamics and structural conditions often drive risk.
The program is centered on "multi-level" interventions, meaning projects are expected to go beyond a single strategy or a single setting. In practical terms, a multi-level HIV prevention approach typically combines components that operate at different layers of influence, such as individual-level supports (for example, counseling, adherence support, risk-reduction skills), interpersonal or network-level elements (partner services, peer navigation, social support), community-level strategies (stigma reduction, community outreach, culturally grounded engagement), and structural or systems-level changes (improving service access, policy or workflow changes in clinics, integration of prevention into routine care, linkage and retention models). The aim is to address not only individual behavior, but also the broader real-world barriers that keep prevention tools from being accessed and used consistently, which is particularly important in communities facing longstanding inequities.
Clinical trials are described as optional under this announcement, which signals flexibility in the types of effectiveness research NIH is willing to support through this R01. Applicants may propose a clinical trial when appropriate, but the opportunity does not require one. The central expectation is that the proposed work will test effectiveness, so study designs should be capable of producing credible evidence about whether the intervention package improves HIV prevention outcomes among the targeted high-risk groups in high-incidence settings.
Eligibility is broad and includes a wide range of public and private entities. Standard eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other organizations as allowed by NIH policy. In addition, the opportunity specifically highlights other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. This wide eligibility signals an interest in encouraging applicants that are closely connected to disproportionately affected communities and regions, including organizations with deep community trust and culturally specific expertise.
From an administrative standpoint, the opportunity was created on February 10, 2023, and the original closing date was April 3, 2023. The award ceiling and the number of expected awards are not specified in the provided source data. Overall, the funding is designed to support research that can demonstrate what works, for whom, and under what real-world conditions, by testing multi-component prevention strategies tailored to people and communities bearing the greatest burden of HIV risk and the greatest impact of health disparities.Apply for RFA MD 23 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307.
- This funding opportunity was created on 2023-02-10.
- Applicants must submit their applications by 2023-04-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: RFA-MD-23-008 (NIH) - Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)
What is the grant opportunity called?
The opportunity is titled "Multi-Level HIV Prevention Interventions for Individuals at the Highest Risk of HIV Infection (R01 Clinical Trial Optional)" and is identified as RFA-MD-23-008.
Which federal agency is offering this opportunity?
The opportunity is offered by the National Institutes of Health (NIH).
What type of grant mechanism does this opportunity use?
It uses the R01 research project grant mechanism.
What funding activity category and CFDA number are associated with this opportunity?
The opportunity falls under the health funding activity category and is associated with CFDA 93.307.
What is the main purpose of this funding opportunity?
The purpose is to support research that rigorously tests the effectiveness of multi-level HIV prevention interventions for people at the very highest risk of acquiring HIV, with a strong emphasis on health disparity populations or specific subgroups.
What does "multi-level" mean in the context of this program?
"Multi-level" means the intervention approach is expected to go beyond a single strategy or setting and combine components that operate across different layers of influence, such as individual, interpersonal or network, community, and structural or systems levels.
What are examples of individual-level components in a multi-level HIV prevention intervention?
Examples include counseling, adherence support, and risk-reduction skill-building.
What are examples of interpersonal or network-level components?
Examples include partner services, peer navigation, and social support approaches.
What are examples of community-level components?
Examples include stigma reduction efforts, community outreach, and culturally grounded engagement strategies.
What are examples of structural or systems-level components?
Examples include improving access to services, clinic policy or workflow changes, integrating prevention into routine care, and linkage and retention models.
Why is there a place-based emphasis in this opportunity?
The opportunity emphasizes focusing work in one or more geographic areas with high rates of new HIV infections. This reflects a place-based approach that considers how local transmission dynamics and structural conditions can drive HIV risk.
Who is the intended target population for the interventions being studied?
The focus is on individuals at the very highest risk of HIV infection, particularly within health disparity populations or specific subgroups.
Is a clinical trial required to apply under this RFA?
No. Clinical trials are optional under this announcement.
If clinical trials are optional, what kind of research is still expected?
The central expectation is that applicants propose work that tests effectiveness. Study designs should be able to produce credible evidence about whether the multi-component intervention improves HIV prevention outcomes among the targeted high-risk groups in high-incidence settings.
What kind of evidence is NIH looking for from funded projects?
Based on the description provided, NIH is looking for rigorous effectiveness evidence showing what works, for whom, and under what real-world conditions, particularly in communities experiencing health disparities and high HIV incidence.
Which types of organizations are eligible to apply?
Eligibility is broad and includes public and private entities such as state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other organizations as allowed by NIH policy.
Are community-based and faith-based organizations eligible?
Yes. The opportunity specifically highlights faith-based or community-based organizations as eligible applicants.
Are minority-serving institutions and historically underrepresented institutions specifically encouraged or eligible?
Yes. The eligibility list specifically highlights Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are specifically highlighted as eligible applicants.
Are foreign organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are specifically highlighted as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are specifically highlighted as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible. The opportunity also highlights Indian/Native American tribal governments other than federally recognized and Native American tribal organizations that are not federally recognized tribal governments.
Does the opportunity specify an award ceiling (maximum award amount)?
No. The provided source data does not specify an award ceiling.
Does the opportunity specify how many awards NIH expects to make?
No. The provided source data does not specify the number of expected awards.
When was this grant opportunity created?
The opportunity was created on February 10, 2023.
What was the original closing date for this opportunity?
The original closing date was April 3, 2023.
What is the overall theme of the research NIH wants to fund through this RFA?
The overall theme is rigorous testing of multi-component HIV prevention strategies tailored to high-risk individuals and communities, especially those experiencing health disparities, with attention to real-world implementation barriers and the geographic contexts where HIV incidence is high.
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