Opportunity Information: Apply for RFA CA 19 029
The NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed), listed as RFA-CA-19-029, is a National Cancer Institute (NCI) grant mechanism under the U.S. Department of Health and Human Services (HHS) and the National Institutes of Health (NIH). Its central goal is to strengthen the pipeline of independent cancer researchers by supporting a select group of outstanding early-stage postdoctoral fellows as they move from a mentored postdoctoral environment into independent, tenure-track (or equivalent) faculty roles. In practical terms, the program is meant to shorten the time it takes for highly prepared postdocs to become independent investigators while ensuring they have resources and structured support during that critical transition.
The award is specifically aimed at postdoctoral researchers who hold a research doctoral degree and/or a clinical doctoral degree and who are already positioned to become independent without needing a long additional period of mentored training beyond what they have completed in their doctoral and postdoctoral work. The intent is not to provide another extended training experience, but to create a clear, supported bridge from a mentored postdoctoral appointment to a first independent academic or equivalent research position. NCI is using this program to maintain a strong cohort of new, talented investigators who can compete successfully for future funding and establish productive cancer-focused research programs.
Structurally, the K99/R00 format is designed as a two-phase pathway. The first phase (K99) supports the applicant while they are still in a mentored postdoctoral position, helping them complete key research and career development steps that position them for independence. The second phase (R00) provides research support after the awardee secures an independent, tenure-track or equivalent position, with the purpose of helping them launch their independent lab or research program and generate the early outputs that make an investigator competitive long-term. Although the provided synopsis does not list specific budget caps (the award ceiling is shown as 0 in the source data), the program description makes clear that the R00 portion is intended to provide independent NCI research support during the transition into a faculty role.
A notable emphasis in this opportunity is NCI's encouragement of applications in data science and cancer control science. This signals that NCI is especially interested in supporting early investigators whose work aligns with modern cancer research needs such as advanced analytics, computational approaches, large-scale data integration, implementation science, prevention, survivorship, healthcare delivery, behavioral research, and population-level strategies to reduce cancer burden. While applications are not limited to these areas, the encouragement indicates these fields are priorities for building the next generation of independent NCI-funded researchers.
The opportunity is classified as a discretionary grant within the education and health activity category (CFDA 93.398). Eligibility, at the organizational level, is broad and includes many types of U.S.-based entities such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses), and various government entities (state, county, city/township, special districts), as well as eligible Native American tribal governments and tribal organizations and public housing authorities/Indian housing authorities. This broad eligibility reflects NIH's typical approach of allowing many organization types to serve as the applicant institution, though the award itself is fundamentally designed to support an individual postdoctoral researcher’s career progression within an eligible sponsoring organization and then within a subsequent independent institution.
The title also specifies "Independent Clinical Trial Not Allowed," which means the mechanism does not permit the awardee to lead an independent clinical trial as part of the funded project. In other words, the supported research should not be structured around the applicant serving as the responsible party for conducting an independent clinical trial. This restriction is important for applicants working near clinical research boundaries, because it shapes the kinds of aims, methods, and study designs that are appropriate under this funding announcement.
From the source data, the funding opportunity was created on December 20, 2018, and the original closing date was February 26, 2019, with an expected number of 16 awards. Overall, the K99/R00 described here is a career-accelerating mechanism that identifies highly promising postdoctoral researchers in cancer-relevant fields and provides a defined, staged path to independence: mentored support to finalize the transition plan and research direction, followed by independent support to establish a competitive, self-sustaining research career under NCI’s mission.Apply for RFA CA 19 029
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.398.
- This funding opportunity was created on Dec 20, 2018.
- Applicants must submit their applications by Feb 26, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 16 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required) Apply for RFA CA 19 030 Funding Number: RFA CA 19 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 022 Funding Number: RFA CA 19 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 021 Funding Number: RFA CA 19 021 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed) Apply for RFA CA 19 020 Funding Number: RFA CA 19 020 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 019 Funding Number: RFA CA 19 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 19 027 Funding Number: RFA CA 19 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trials Optional) Apply for RFA CA 19 025 Funding Number: RFA CA 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 19 026 Funding Number: RFA CA 19 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 19 023 Funding Number: RFA CA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 19 024 Funding Number: RFA CA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Distance Learning and Telemedicine Grants. Apply for RUS 19 02 DLT Funding Number: RUS 19 02 DLT Agency: Department of Agriculture, Utilities Programs Category: Education, Health Funding Amount: $500,000 |
| Distance Learning and Telemedicine Grants--Opioid. Apply for RUS 19 01 DLT Funding Number: RUS 19 01 DLT Agency: Department of Agriculture, Utilities Programs Category: Education, Health Funding Amount: $500,000 |
| Feasibility and Planning Studies for Development of Specialized Programs of Research Excellence (SPOREs) to Investigate Cancer Health Disparities (P20 Clinical Trial Optional) Apply for RFA CA 19 034 Funding Number: RFA CA 19 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $800,000 |
| Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care (R01 Clinical Trial Required) Apply for RFA CA 19 035 Funding Number: RFA CA 19 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| American Schools and Hospitals Abroad Program Worldwide Apply for 72ASHA19RFA00001 Funding Number: 72ASHA19RFA00001 Agency: Agency for International Development Category: Education, Health Funding Amount: $2,000,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 19 062 Funding Number: RFA CA 19 062 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 19 061 Funding Number: RFA CA 19 061 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trials Optional) Apply for RFA CA 19 063 Funding Number: RFA CA 19 063 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Required) Apply for RFA DA 20 024 Funding Number: RFA DA 20 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Limited Competition: Pediatric Brain Tumor Consortium (UM1 Clinical Trials Required) Apply for RFA CA 19 059 Funding Number: RFA CA 19 059 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,300,000 |
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