Opportunity Information: Apply for PAR 25 377
The NIH funding opportunity PAR 25-377, titled "Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)," is an R01 research grant solicitation aimed at improving understanding of health and healthcare disparities tied to the non-communicable and chronic diseases (NCDs) that drive the greatest burden of illness and death in Latin America and among Hispanics/Latinos living in the United States. The core idea is to generate practical, policy-relevant evidence that helps explain where disparities come from, how they persist across communities and health systems, and what measurement tools and analytic approaches are strong enough to guide action. Clinical trials are explicitly not allowed under this NOFO, so the emphasis is on observational and evaluative research rather than testing clinical interventions in a trial format.
The NOFO is designed to support innovative, collaborative, multi-disciplinary projects, particularly those grounded in clinical epidemiology, evaluation of public and/or healthcare policies, and validation of measurements. In practice, that points to studies that can map inequities in disease risk, diagnosis, treatment, and outcomes; analyze how structural and social factors shape those inequities; and assess the effects of real-world policies or healthcare delivery changes on different populations. It also highlights measurement validation, meaning applicants can focus on strengthening the tools used to quantify disparities, such as validating survey instruments, risk scores, clinical measures, administrative data algorithms, or harmonized indicators that can be applied across countries or across Latino/Hispanic subgroups. The goal is to ensure the field is working with reliable, comparable measures that can support credible cross-setting conclusions and better decision-making.
A defining requirement is meaningful partnership with Latin America. Multi-disciplinary research teams are expected to collaborate closely with key partners, and the project leadership must include at least one Principal Investigator (PI) or Multiple Principal Investigator (MPI) based at an institution in Latin America. This requirement signals that NIH is looking for research that is not simply about Latin America, but done with Latin American institutions in leadership roles, supporting shared governance, contextual expertise, and stronger regional relevance. The intent is to foster equitable collaborations that combine local knowledge, data access, and health system realities with rigorous analytic methods and cross-border comparative perspectives.
The populations and settings of interest span both Latin America and U.S. Hispanics/Latinos, reflecting a hemisphere-wide framing of disparities. That opens the door to research that examines common drivers of inequity across countries, migration and transnational factors, and differences among Hispanic/Latino groups by ancestry, national origin, geography, socioeconomic position, or access to insurance and care. Because the NOFO emphasizes the NCDs with the highest burden and mortality, projects would be expected to focus on major chronic disease areas that dominate morbidity and mortality profiles in the region and in U.S. Latino communities, while staying aligned with the specific priorities described in the full announcement.
Eligibility is broad and includes many types of U.S.-based applicants and organizations, such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The NOFO also explicitly calls out several categories of organizations as eligible applicants or relevant partners, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments (other than federally recognized), regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions. This wide eligibility is consistent with a disparities-focused initiative that benefits from community-connected institutions and diverse organizational capabilities.
At the same time, the opportunity draws important boundaries around foreign applications. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply directly, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed. In practical terms, this means the applicant organization must be eligible under NIH rules (typically U.S.-based), but the research can include foreign components and collaborations in Latin America, and the leadership structure must include at least one PI or MPI from a Latin American institution. That combination is meant to preserve NIH’s applicant eligibility framework while still enabling substantial on-the-ground work and shared leadership across the hemisphere.
Administrative details provided include that this is a discretionary grant under the NIH umbrella, tied to CFDA numbers 93.121, 93.307, 93.313, 93.361, 93.393, and 93.866. The original closing date listed is January 7, 2027. Award ceiling and expected number of awards are not specified in the provided text, which usually means applicants should consult the full NOFO for budget expectations, project period limits, and any institute- or center-specific guidance. Overall, the opportunity is positioned to build a stronger evidence base on how chronic disease disparities arise and can be measured and addressed, with an explicit expectation that U.S. and Latin American investigators co-lead rigorous research that can inform policy, health system improvements, and future interventions across the hemisphere.Apply for PAR 25 377
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.307, 93.313, 93.361, 93.393, 93.866.
- This funding opportunity was created on 2025-01-08.
- Applicants must submit their applications by 2027-01-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is PAR-25-377?
PAR-25-377 is an NIH funding opportunity titled "Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)." It uses the NIH R01 research grant mechanism and focuses on understanding health and healthcare disparities related to high-burden non-communicable and chronic diseases (NCDs) in Latin America and among Hispanics/Latinos living in the United States.
What is the main purpose of this funding opportunity?
The purpose is to generate practical, policy-relevant evidence explaining where disparities come from, how they persist across communities and health systems, and which measurement tools and analytic approaches are strong enough to guide action. The emphasis is on producing evidence that can inform decision-making (for example, public policy and healthcare delivery improvements), rather than running clinical intervention trials.
What grant mechanism is being used?
This opportunity uses the NIH R01 mechanism.
Are clinical trials allowed under this NOFO?
No. Clinical trials are explicitly not allowed. The emphasis is on observational and evaluative research rather than testing clinical interventions in a trial format.
What types of studies does NIH appear to be looking for?
Based on the description provided, NIH is looking for innovative, collaborative, multi-disciplinary projects grounded in areas such as clinical epidemiology, evaluation of public and/or healthcare policies, and measurement validation. Examples of aligned work include mapping inequities in disease risk, diagnosis, treatment, and outcomes; analyzing structural and social drivers of inequities; and assessing the effects of real-world policies or healthcare delivery changes on different populations.
What does "measurement validation" mean in the context of this opportunity?
Measurement validation refers to strengthening the tools used to quantify disparities so results are reliable and comparable across settings. This can include validating survey instruments, risk scores, clinical measures, administrative data algorithms, or harmonized indicators that can be applied across countries or across Latino/Hispanic subgroups.
What is the geographic and population focus?
The focus spans Latin America and Hispanics/Latinos living in the United States, using a hemisphere-wide framing of disparities. This includes the possibility of studying common drivers of inequity across countries, migration and transnational factors, and differences among Hispanic/Latino groups by ancestry, national origin, geography, socioeconomic position, or access to insurance and care.
Which health conditions are the priority?
The emphasis is on non-communicable and chronic diseases (NCDs) that drive the greatest burden of illness and death in Latin America and among Hispanics/Latinos in the United States. Specific disease areas are not listed in the provided text, beyond the focus on high-burden and high-mortality chronic conditions.
Is collaboration with Latin America required?
Yes. A defining requirement is meaningful partnership with Latin America, with close collaboration among key partners and a multi-disciplinary team structure.
Is a Latin America-based Principal Investigator required?
Yes. Project leadership must include at least one Principal Investigator (PI) or Multiple Principal Investigator (MPI) based at an institution in Latin America.
What is NIH signaling by requiring Latin America-based leadership?
The requirement indicates NIH is looking for research not simply about Latin America, but conducted with Latin American institutions in leadership roles. The stated intent is shared governance, contextual expertise, and stronger regional relevance, fostering more equitable collaborations.
Can a non-U.S. (foreign) organization apply directly as the applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply directly, based on the information provided.
Are non-domestic components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are not eligible to apply, based on the information provided.
Are foreign components allowed as part of the research?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed. In practical terms, the applicant organization must be eligible under NIH rules (typically U.S.-based), while the work can include foreign components and collaborations in Latin America, and leadership must include at least one PI or MPI from a Latin American institution.
What types of U.S.-based organizations are eligible to apply?
Eligibility is described as broad and includes (among others): state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses.
Are certain institution types specifically called out as eligible applicants or relevant partners?
Yes. The text explicitly calls out categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments (other than federally recognized), regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.
Does this opportunity encourage community-connected or regionally engaged organizations?
The wide eligibility described, including community-based organizations, faith-based organizations, and minority-serving institutions, aligns with the disparities-focused nature of the opportunity and suggests value in community-connected capacity and diverse organizational roles.
What kinds of outcomes is NIH trying to enable through this research?
The stated aim is to build a stronger evidence base on how chronic disease disparities arise, persist, and can be measured credibly, so that the findings can inform policy, health system improvements, and better decision-making across the hemisphere.
What is the application deadline (closing date) listed in the provided information?
The original closing date listed is January 7, 2027.
Is there an award ceiling or an expected number of awards stated?
No. The award ceiling and expected number of awards are not specified in the provided text.
What should applicants do if they need budget expectations or project period limits?
Because the ceiling and number of awards are not specified in the provided information, applicants would typically need to consult the full NOFO for budget expectations, project period limits, and any institute- or center-specific guidance.
What type of federal assistance listing information is included?
The opportunity is described as a discretionary grant under NIH and is tied to CFDA numbers 93.121, 93.307, 93.313, 93.361, 93.393, and 93.866.
Does the opportunity emphasize single-discipline or multi-disciplinary teams?
It emphasizes innovative, collaborative, multi-disciplinary projects, with an expectation of close collaboration with partners and leadership involvement from Latin America.
Is the research expected to be policy-relevant?
Yes. The description repeatedly emphasizes practical, policy-relevant evidence, including evaluation of public and/or healthcare policies and real-world healthcare delivery changes as they affect different populations.
Can a project focus on differences within U.S. Hispanic/Latino populations?
Yes. The text highlights differences among Hispanic/Latino groups by ancestry, national origin, geography, socioeconomic position, or access to insurance and care as relevant to the hemisphere-wide disparities framing.
Can projects compare disparities across countries or across subgroups?
Yes. The emphasis on harmonized indicators and comparable measurement tools, along with the Latin America and U.S. framing, supports cross-setting and cross-subgroup comparisons when appropriate.
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