Opportunity Information: Apply for RFA OD 20 005
The Transformative Research Award for the NIH INCLUDE Project is a discretionary NIH grant opportunity (R01 mechanism; clinical trial not allowed) designed to push Down syndrome research in bold, paradigm-shifting directions. The program is aimed at proposals that are genuinely groundbreaking and unusually innovative, including ideas that may be original or unconventional as long as the underlying scientific logic is strong and the potential payoff is high. The core expectation is that the work could meaningfully reshape how the field understands Down syndrome and co-occurring conditions across the lifespan, lead to entirely new or substantially improved clinical approaches (without being a clinical trial under this announcement), or enable transformative technologies that open up new lines of investigation.
A key feature of this opportunity is that it explicitly welcomes high-risk, high-reward concepts by not requiring preliminary data. That said, the application still needs to make a compelling, well-reasoned case that the approach is sound and that the outcomes, if successful, would have major impact on Down syndrome research. The scope is broad: applicants can propose projects in any topic area that is relevant to Down syndrome, particularly research aligned with the INCLUDE Project mission of understanding conditions that co-occur with Down syndrome across different stages of life. The emphasis is less on incremental next steps and more on ideas that could change assumptions, create new frameworks, or dramatically advance capability in the field.
Eligibility is wide and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, special district governments, independent school districts, and federally recognized tribal governments. A broad range of academic institutions can apply, including public/state-controlled and private institutions of higher education. The announcement also allows participation from nonprofit organizations (both with and without 501(c)(3) status), public housing authorities/Indian housing authorities, and tribal organizations that are not federally recognized tribal governments. For-profit entities (other than small businesses) and small businesses are eligible as well, along with other organization types listed by NIH.
The announcement also highlights additional eligible applicant categories that NIH specifically encourages, reflecting an interest in broad participation and diverse perspectives. These include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments other than federally recognized ones, and U.S. territories or possessions.
On the foreign participation rules, the opportunity draws an important distinction. Non-domestic (non-U.S.) entities or foreign institutions are not eligible to apply directly as the applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components are allowed when they meet the NIH definition in the NIH Grants Policy Statement. In practice, this means the main applicant must be a domestic eligible organization, but certain parts of the work may be conducted abroad through allowable foreign components, consistent with NIH policy.
Administrative details from the source listing include the funding opportunity title and number (RFA-OD-20-005), the sponsoring agency (National Institutes of Health), the funding instrument type (grant), and the activity category spanning health-related CFDA program areas. The original closing date shown is November 3, 2021, and the listing does not specify an award ceiling or expected number of awards in the provided text.Apply for RFA OD 20 005
- The National Institutes of Health in the environment, health, income security and social services sector is offering a public funding opportunity titled "Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.233, 93.242, 93.310, 93.351, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2019-12-13.
- Applicants must submit their applications by 2021-11-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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